Detection of antimicrobial resistance and OXA genes in imipenem-resistant Acinetobacter baumannii from Hohhot region
10.3969/j.issn.1671-9638.2015.05.001
- VernacularTitle:呼和浩特地区耐亚胺培南鲍曼不动杆菌耐药性及OXA 基因检测
- Author:
Chaomei LIU
;
Xuemei LI
;
Zhiying CHEN
;
Xiaohua ZHENG
;
Sufang GUO
- Publication Type:Journal Article
- Keywords:
Acinetobcter baumannii;
drug resistance,microbial;
carbapenemase;
OXA gene;
rational drug use
- From:
Chinese Journal of Infection Control
2015;(5):289-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To realize antimicrobial resistance and carrying status of OXA carbapenemase among imi-penem-resistant Acinetobacter baumannii (IRAB)isolated from patients of Hohhot,so as to provide guidance for the prevention and control of healthcare-associated infection(HAI)caused by multidrug-resistant Acinetobacter bauman-nii .Methods 49 IRAB isolates from 3 tertiary first-class hospitals in Hohhot between January and December 2012 were collected,antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion method,four geno-types(blaOXA-51-like ,blaOXA-23-like ,blaOXA-24-like ,blaOXA-58-like )of OXA carbapenemase were detected by polymerase chain reaction (PCR).Results All 49 isolated IRAB strains were found to be highly resistant to antimicrobial agents (81 .63%-100.00%)except to minocycline (8.16%);blaOXA-51-like was identified in 49 strains (100.00%),42 (85.71 %)of which also carried blaOXA-23-like gene ,blaOXA-23-lik and blaOXA-51-like were both found in three hospital, blaOXA-24-like and blaOXA-58-like weren’t found.Conclusion IRAB strains present multidrug resistance,resistant to mi-nocycline is the lowest;blaOXA-23-like is the main drug-resistance mechanism of IRAB in Hohhot.
