Enterovirus types and clinical characteristics of 5 070 cases with hand,foot and mouth disease in Shen-yang area,2014
10.3760/cma.j.issn.1673-4912.2015.06.013
- VernacularTitle:2014年沈阳地区5070例手足口病患儿病原分布及临床特征
- Author:
Zhiqiang NIU
;
Yaohua JI
;
Guohe FENG
;
Shuqin LI
- Publication Type:Journal Article
- Keywords:
Hand,food and mouse disease;
Enterovirus 71;
Coxsackievirus A 16;
Universal Entero-viruses
- From:
Chinese Pediatric Emergency Medicine
2015;22(6):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the epidemic characteristics,distribution of pathogen and clinical characteristics of hand,foot and mouth disease in Shenyang area,2014.Methods Swab specimens was collected from 5 070 cases of hand,foot and mouth disease caces,the F-PCR method was adopted for entero-virus 71 (EV71 ),coxsackievirus A 16(CA16)and universal enteroviruses(EU)detection,and combining the relevant clinical data for comparative analysis .Results June to August was the peak epidemic period.5 070 nasopharyngeal swab specimens were detected positive 3 715 intestinal virus nucleic acid,and the detection rate was 73.27%,including CA16 positive 1 481 (39.87%),EU positive 1 148 (30.90%),EV71 positive 1 086(29.23%).The proportion of EU positive was highest in June(29.71 %).The proportion of EV71 pos-itive(24.78%)and CA16 positive(33.27%)were highest in July,respectively .The proportion of nervous system symptoms in EV71 infection group(88 /1 12,78.57%)was higher than those in EU infection group (97 /147,65.99%)and CA16 infection group (44 /78,56.41 %).The proportion of abnormal myocardial enyzme in CA16 infection group (37 /78,47.44%)was higher than those in EU infection group (48 /147, 32.65%)and EV71 infection group(34 /1 12,30.36%).Conclusion CA16 is the major pathogen causing hand,foot and mouth disease in Shenyang area,2014.Severe hand,foot and mouth is still dominated by EV71 .
