Glibenclamide for the prevention of cerebral edema and hemorrhagic transformation in ischemic stroke
10.3760/cma.j.issn.1673-4165.2015.05.012
- VernacularTitle:格列本脲预防缺血性卒中患者脑水肿和出血性转化
- Author:
Hongyan CHEN
;
Hongjun WANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Brain Edema;
Cerebral Hemorrhage;
Glyburide;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2015;(5):383-387
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral edema and hemorrhagic transformation(HT) are the common complications of ischemic stroke. Ischemic cerebral edema is the primary cause of death in patients w ith large infarction. The sulfonylurea receptor 1 (Sur1) transient receptor potential M4 (Trpm4) channel plays an important role in focal cerebral ischemia. Both animal experiment and clinical studies have show n that the Sur1 selective inhibitor glibenclamide provides neuroprotection for ischemic stroke, including infarct volume reduction and improvement of neurological function, especial y in attenuating cerebral edema and reducing the incidence of HT. This article review s the advances in research on glibenclamide for the prevention of cerebral edema and HT in patients w ith ischemic stroke.
