The ABCG2 gene rs2231142 polymorphism contributes to the increased risk for gout:a meta-analysis
10.3760/cma.j.issn.1007-7480.2015.06.006
- VernacularTitle:三磷酸腺苷结合盒亚家族G超家族第二个成员（ABCG2）基因rs2231142多态性与痛风发病风险的Meta分析
- Author:
Ya QIU
;
Hua LIU
;
Jingguo ZHOU
;
Yufeng QING
;
Mingcai ZHAO
;
Wenguang XIE
;
Wantai DANG
- Publication Type:Journal Article
- Keywords:
Gout;
Meta-analysis;
ABCG2 gene;
rs2231142;
Polymorphism
- From:
Chinese Journal of Rheumatology
2015;(6):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study is aimed to evaluate the association between the ABCG2 gene rs2231142 variant and gout using meta-analysis. Methods Related studies were identified by searching extensively in Chinese and foreign language databases such as Pubmed, EMBASE, Cochrane Library, CBMdisc databases and so on. The quality of included studies was assessed by using the Newcastle-Ottawa Scale (NOS). The odds ratio (OR) was calculated using a random-effects or fixed-effects model. A Q statistic was used to evaluate the heterogeneity, and Eggerˊs test and funnel plot were used to assess publication bias. Sub-group analyses on ethnicities and sex were also performed. Results A total of 10 studies, including 3 478 gout patients and 10,089 controls from 6 countries or regions, were included and identified for the current metaan-alysis. It was found that the A allele or AA genotype of the ABCG2 rs2231142 polymorphism had an increased risk for gout in the general population [A allele: OR=2.03, 95%CI (1.77, 2.34), P<0.01 and AA genotype: OR=3.01, 95%CI (2.34, 3.88), P<0.01, respectively]. Similar results were found in sub-group analyses of different gender and races. Conclusion Existing evidence indicate that rs2231142 polymorphism (the A allele and AA genotype) is associated with increased risk of gout.
