Research update on PD-1 and its ligand PD-L1 in malignant tumor
10.3760/cma.j.issn.1673-422X.2015.05.010
- VernacularTitle:程序性死亡受体-1及其配体在恶性肿瘤中的研究进展
- Author:
Jingyi SHAO
;
Guoping SUN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Programmed death-1
- From:
Journal of International Oncology
2015;(5):358-360
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death1-ligand(PD-L1)is a new member of B7 family,whose receptor is pro-grammed death-1(PD-1). The interaction between PD-L1 and PD-1 can down-regulate the activation of immune response. There are some differences in the expression of PD-1 and PD-L1 in normal tissues and tumor tissues, which may provide a new way for the immunotherapy of carcinoma.
