Development of ABCC4 on various tumors and chemotherapy drugs
10.3760/cma.j.issn.1673-422X.2015.05.013
- VernacularTitle:ATP 结合转运蛋白 C4与肿瘤及化疗药物的研究进展
- Author:
Jin YAN
;
Xiaoting ZHAO
;
Mei JIANG
;
Wentao YUE
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Drug therapy;
Drug resistance,neoplasm;
ATP-binding cassette transporter C4
- From:
Journal of International Oncology
2015;(5):367-370
- CountryChina
- Language:Chinese
-
Abstract:
ATP binding cassette C4(ABCC4,MRP4)plays an important role in transshipment physio-logic,endogenous or exogenous substances. The over expression of ABCC4 gene has been found in many kinds of solid tumors and hematological malignancies. The target gene also influences metastasis and recurrence process. ABCC4 can reduce the intracellular concentration and the sensitivity of various chemotherapy drugs, which is bad for prognosis.
