Molecular biomarkers related prognosis in hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2015.05.021
- VernacularTitle:肝细胞癌预后相关细胞分子生物标志物研究进展
- Author:
Baoguo LI
;
Zhi GUO
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
MicroRNAs;
Cell cycle;
Neoplastic stem cells
- From:
Journal of International Oncology
2015;(5):395-398
- CountryChina
- Language:Chinese
-
Abstract:
The occurence and progress of hepatocellular carcinoma(HCC)is a complex network inter-action process connected by multiple signaling pathways involving genes,cells and various active molecules. The effects and functions of biological molecular markers also vary among different pathways. Moreover,wheth-er the molecular markers have prediction effects for the prognosis of HCC remains unclear,and studies investing this issue are still insufficient. The current studies reveal that molecular markers involves in multiple pathways including gene expression,gene regulation,cell cycle regulation,cancer stem cell proliferation and differentia-tion. These processes are intimately associated with the occurrence and prognosis of HCC. The relevant gene or molecular that may indicate the prognosis of HCC includes p53 gene,long non-coding RNA,cell cycle regula-tors,liver cancer stem cell surface-associated molecules,etc.
