Research progress on animal models of depression and their evaluation methods
10.3969/j.issn.1005-4847.2015.03.019
- VernacularTitle:抑郁症动物模型及评价方法研究进展
- Author:
Tao XUE
;
Lisha WU
;
Xinmin LIU
;
Qiong WANG
- Publication Type:Journal Article
- Keywords:
Depression;
Animal model;
Behavior;
Biochemical criteria;
Evaluation methods
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;(3):321-326
- CountryChina
- Language:Chinese
-
Abstract:
Depression, a seriously harmful disease to peoples ’ physical and mental health , is prevailing world-wide.But the etiology and pathological mechanism is still not fully uncovered .With the development of social economy and the pace of life speeding up , increasing pressure and vulnerable emotion cause depression incidence increased rapidly .For the further research on depression , study of depression mechanism and antidepressant drugs highly depends on effective ani -mal models .The degree of similarity of animal models to human disease status and the accuracy and reliability of evaluation methods of animal models directly influence the value of the resuts of experiments .In this article we introduce the common-ly used animal models of depression , the evaluation indicators at organism , organ, and molecular levels , and to provide theoretical references for the further studies on depression .
