Triple combination therapy using saxagliptin/metformin/rosiglitazone versus intensive insulin therapy in the treatment of newly-diagnosed type 2 diabetes:Effects on glycaemic control andα/β-cell function
10.3760/cma.j.issn.1000-6699.2015.06.009
- VernacularTitle:对比沙格列汀、二甲双胍联合罗格列酮的三联方案与胰岛素强化方案治疗初诊断2型糖尿病患者的有效性及对α、β细胞功能的影响
- Author:
Huijin LUO
;
Rongping CHEN
;
Rui YANG
;
Zhen ZHANG
;
Min YI
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Triple combination therapy;
Intensive insulin therapy;
α-cell,β-cell
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(6):515-517
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] Drug naive, newly diagnosed type 2 diabetic subjects were randomized to Saxagliptin/Metformin / Rosiglitazone(Triple Therapy, n=23) or insulin 70 30 mix group(Intensive Insulin Therapy) (n=21) for 24 weeks. How did the 2 therapies influence fasting blood glucose, fasting insulin, C-peptide, and glucagon levels and the change of body weight were compared. This study was aimed to explore the comparative glycemic efficacy and impact on α/ β-cell function of two different antidiabetic therapies, triple combination therapy using saxagliptin/metformin/ rosiglitazone and intensive insulin therapy, for newly diagnosed type 2 diabetes mellitus. The results indicated that fasting blood glucose, HbA1C , insulin resistance index 2(HOMA 2-IR), glucagon and body mass index level were significantly decreased, and insulin secretion index 2 ( HOMA 2-% β) was increased significantly( P <0. 05) in triple therapy group, and the decreasing extent of HOMA 2-IR, glucagon, and body mass index were significantly greater than that in the intensive insulin group(P<0. 05). Triple therapy group has a stronger effect of reducing insulin resistance, as well as on inhibiting glucagon and promoting weight loss.
