The main effect and interaction between haplotypes of CIDEB and CIDEC to obesity

VernacularTitle:CIDEB、CIDEC 基因单倍型及单倍型交互作用与肥胖的关系
Author: Zhiguang PING ; Li LIU ; Fangfang ZHAN ; Minjie QI ; Xiaoping LE
Publication Type:Journal Article
Keywords: CIDE gene; Haplotype; Obesity; Interaction
From: Chinese Journal of Endocrinology and Metabolism 2015;(6):518-521
CountryChina
Language:Chinese
Abstract: [Summary] A selection of 528 unrelated subjects were enrolled(198 males, 330 females) with the mean age of(52. 23 ± 13. 41) years old. According to body mass index, 253 persons belonged to the normal weight group and 275 persons overweight/ obesity group. A total of 10 SNPs in CIDEB and CIDEC genes were detected. SHEsis online were used to get the haplotypes of these two genes. The relationship between above SNPs and obesity were analyzed under additive inheritance pattern. The main effects and interaction on obesity induced by two genes’ haplotypes were analyzed by logistic regression. rs2144493 in CIDEB gene was associated with obesity, C was a protective alleles, OR (95% CI) equals 0. 722(0. 525-0. 992). CCTT haplotype of CIDEB gene carriers and GCG haplotype of CIDEC gene carriers were more prone to obesity or overweight, there was an interaction between the haplotypes of 2 genes. CIDEB, CIDEC haplotypes may play independent and interactive roles in causing obesity.