The Role of Radiotherapy in Treatment of Hepatocellular Carcinoma.
10.12701/yujm.2000.17.2.137
- Author:
Jong Ryul EUN
;
Kyo Won CHOI
;
Heon Ju LEE
;
Mung Se KIM
- Publication Type:Original Article
- Keywords:
Radiotherapy;
Hepatocellular carcinoma
- MeSH:
Ascites;
Carcinoma, Hepatocellular*;
Female;
Humans;
Liver Cirrhosis;
Male;
Radiotherapy*;
Survival Rate
- From:Yeungnam University Journal of Medicine
2000;17(2):137-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hepatocellular carcinomal(HCC) has been considered to be relatively radioresistant. The role of radiotherapy(RT) in the treatment of HCC is controversial. But RT has a role in the treatment of hepatocellular carcinoma as a single or combination modalities. The effect of radiotherapy on HCC was evaluated. Patients and METHODS: From January 1984 through January 2000, a total of 18 patients with unresectable HCC underwent radiotherapy alone or in conjunction with transarterial embolization(TAE). We reviewed the medical ecords of patients treated with RT and measured the tumor size using measured the tumor size using planimetry method. The Kaplan-Meier method was used to calculate the survival rate. RESULTS: The RT patients were 15 men and 3 women. The mean age was 51 years. four(22.2%) of them were accompanied with ascites. Eleven(61.1%) of them were accompanied with liver cirrhosis and their functions were 6, 3, 2 in each Child-Pugh A, B, C, respectively. A partial response(PR) was observed in 2 patients(11.1%), minimal response(MR) in 4 patients (22.2%) and no change(NC), in 11 patients(61.1%), whereas progressive disease(PD) was seen in 1 patients(6%), respectively. CONCLUSIONS: Although the radiotherapy in HCC did not improve the survival rate. it decreased the tmor size. Radiotherapy strengthens the therapeutic efficacy when combined with TAE, but more studies are needed.
