Neutrophil/lymphocyte ratio and type 2 diabetes in men and women
10.3760/cma.j.issn.1674-0815.2015.03.007
- VernacularTitle:中性粒细胞/淋巴细胞比值与2型糖尿病的关联研究
- Author:
Qiyu JIA
;
Xiaoyan GUO
;
Hongbin SHI
;
Li LIU
;
Kun SONG
;
Qing ZHANG
;
Kaijun NIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Biological markers;
Neutrophil to lymphocyte ratio
- From:
Chinese Journal of Health Management
2015;(3):177-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective Neutrophil/lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker but few studies have assessed the relationship between NLR and type 2 diabetes. In order to evaluate how NLR is related to type 2 diabetes, we designed a large scale cross?sectional study in an adult population. Method A cross?sectional study (including 49 861 men and 40 376 women) was conducted on participants recruited from the Health Management Center of Tianjin Medical University General Hospital in Tianjin, China. Measurements of neutrophil and lymphocyte counts, fasting blood glucose and other potential confounding factors were performed. Type 2 diabetes was defined according to the criteria of American Diabetes Association. Adjusted logistic regression models were used to assess relationships between NLR quintiles and type 2 diabetes. Result In the final multivariate models, the odds ratios (95% confidence interval) for T2D across NLR quintiles were 1.00 (Reference), 1.19 (1.05, 1.35), 1.33 (1.17, 1.50), 1.28 (1.13, 1.44) and 1.34 (1.19, 1.51) (P for trend<0.000 1), in men. Similar relationships were also observed in women. Conclusion This study demonstrated that NLR was related to the prevalence of type 2 diabetes in men and women, and suggesting that NLR may be an efficient and accurate prognostic biomarker for type 2 diabetes.
