The effect of p70S6K1 and 4EBP1 protein in colorectal cancer
10.3760/cma.j.issn.1673-422X.2015.05.020
- VernacularTitle:p70S6K1及4E-BP1蛋白在结直肠癌中的作用
- Author:
Shaohua ZHANG
;
Jingwang BI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Ribosomal protein S6 kinases;
Eukaryotic initiation factor-4E
- From:
Journal of International Oncology
2015;(5):392-394
- CountryChina
- Language:Chinese
-
Abstract:
The phosphatidylinositide-3-kinase(PI3K)/ protein kinase B(Akt)/ mammalian target of rapamycin(mTOR)pathway is recognized to have an important role in the development and progression of colo-rectal cancer(CRC). The most extensively characterized downstream targets of mTORC1 are ribosomal protein S6 kinase 1(p70S6K1)and eukaryotic translation initiation factor(eIF)4E-binding protein 1(4EBP1),both of which are crucial to the regulation of protein synthesis. The abnormal expression of p70S6K1 and 4EBP1 in CRC has become the focus of attention.
