Effect of refraction and axial length on retinal nerve fiber layer thickness and optic disc morphology in guinea pigs
10.3969/j.issn.1005-4847.2015.03.012
- VernacularTitle:屈光度和眼轴长度对豚鼠视网膜神经纤维层厚度和视乳头形态的影响
- Author:
Tao LI
;
Xiaodong ZHOU
;
Hanran JIANG
;
Jie ZHU
- Publication Type:Journal Article
- Keywords:
Guinea pig;
Retinal nerve fiber layer thickness;
Optic disc morphology;
Optical coherence tomo-graphy
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;(3):285-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the retinal nerve fiber layer ( RNFL) thickness and optic disc morphology in guinea pigs by optical coherence tomography ( OCT ) , and to investigate the correlation of spherical equivalent and axial length with those parameters .Methods Twenty healthy guinea pigs were used in this study .Spherical equivalent and axi-al length of nine guinea pigs were measured , and retinal nerve fiber layer thickness and optic disc morphology in the guinea pigs were analyzed by OCT .Results Spherical equivalent of the guinea pigs was positively correlated with average RNFL thickness, and with superior, temporal, inferior and nasal RNFL thicknesses;while ocular axial length was negatively cor-related with average RNFL thickness , and with superior , temporal , inferior and nasal RNFL thicknesses .Spherical equiva-lent and axial length did not correlate significantly with disc edge area , optic disc area , average cup disc ratio , or cup vol-ume .Vertical cup disc ratio significantly correlated with axial length , but did not with spherical equivalent .Conclusions The retinal nerve fiber layer thickness in guinea pigs is affected by both spherical equivalent and axial length .When guinea pigs are used as an animal model of glaucoma , the effect of refractive state and axial length should be considered .
