Clinical efficacy of patient-controlled intravenous analgesia for intractable cancer pain
10.3969/j.issn.1000-8179.20141796
- VernacularTitle:静脉自控镇痛治疗顽固性癌痛的临床疗效分析
- Author:
Jianguang LIN
;
Tianwen XU
;
Fangwei XIE
;
Deqiang FU
;
Yijun DAI
;
Aiyue ZHAO
- Publication Type:Journal Article
- Keywords:
pain;
analgesia;
cancer;
treatment costs
- From:
Chinese Journal of Clinical Oncology
2015;(12):586-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical efficacy of oxycodone hydrochloride controlled-release tablets (OHCT) and pa-tient-controlled intravenous analgesia (PCIA) in the treatment of intractable cancer pain. Methods:Retrospective analysis was conduct-ed to evaluate the intractable cancer pain of 89 elderly patients who were admitted to the medical oncology departments of The Second Affiliated Hospital of Fujian Medical University and the Fuzhou General Hospital of Nanjing Military Command between September 2012 and March 2014. Among the 89 patients, 47 were treated with OHCT, and 42 received PCIA. The total dosage ranged from 60 mg/d to 400 mg/d PO q12h for patients in the OHCT group, whereas abackground dose+patient-controlled dosemode was adopted for patients in the PCIA group. The therapeutic efficacy, presence of adverse reactions, cost of treatment, and degree of patient satisfaction were compared between the two groups. Results:The average dosages of analgesics in the two groups were almost the same (P>0.05). Visual analogue scale (VAS) values and daily average VAS values were both lower in the PCIA group than in the OHCT group at 24 h after analgesia (P<0.05). The incidence of adverse reactions, such as nausea and vomiting, was also lower in the PCIA group than in the OHCT group (P<0.05). The cost of treatment and degree of patient satisfaction were the same in both groups (P>0.05). Conclusion:Pa-tients who received PCIA attained better analgesia and exhibited less adverse reactions than those who received OHCT whereas the treatment cost and patient satisfaction did not differ in both groups.
