Interventional effect of cisplatin combined with fluoxetine on mice bearing Lewis lung cancer with depression
10.3969/j.issn.1005-4847.2015.03.001
- VernacularTitle:顺铂联合氟西汀对肺癌伴抑郁小鼠干预的研究
- Author:
Mihui LI
;
Xiao WU
;
Kai WEI
;
Yanhua LIN
;
Ying WEI
;
Jing SUN
;
Qingli LUO
;
Baojun LIU
;
Jingcheng DONG
- Publication Type:Journal Article
- Keywords:
Lung cancer with depression;
Fluoxetine;
Cisplatin;
Nuclear factor-kapppa B
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;(3):221-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe if fluoxetine has a potency to inhibit the progression of Lewis lung cancer by combining the fluoxetine and cisplatin to treat the mice bearing Lewis lung cancer with depression .Methods We devel-oped a mouse model of Lewis lung cancer with depression which was intervened with cisplatin and fluoxetine , and the indi-cators related to cancer and depression were tested .Social interaction test was used to measure the behavioral changes of the depressed model mice .The serum cortisol and IL-6, BDNF mRNA in the hippocampus , and NF-κB and VEGF in the tumor tissue were selected for investigation and comparison .Results The mice which were induced by social defeat exhib-ited social avoidance behavior in the social interaction test .The cortisol and IL-6 level in both combination groups was de-creased compared with that in the model group (P<0.05), and the cortisol and BDNF mRNA in the combination group in-creased signifuicantly ( P <0.05 ) .There were no statistically significant differences in the tumor weight , NF-κB and VEGF in tumor tissues between the single and combination groups (P>0.05).Conclusions Fluoxetine has antidepres-sant effect by decreasing the high level of serum cortisol and promoting the BDNF mRNA expression in the hippocampus . However , fluoxetine is not found to have the potency to inhibit the expression of NF -κB related with the progression of tumor.
