Brain gray matter changes in essential arm tremor patients:Voxel-based morphometry

VernacularTitle:应用基于体素的形态测量学方法分析原发性手震颤患者灰质体积变化
Author: Hongmei CAO ; Rong WANG ; Xianjun LI ; Xue LUO ; Jian YANG ; Qiumin QU
Publication Type:Journal Article
Keywords: essential tremor; magnetic resonance image; morphometry; brain gray matter
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2015;(4):509-513
CountryChina
Language:Chinese
Abstract: Objective To investigate the abnormalities of brain gray matter volume in patients with clinically-confirmed essential tremor (ET)of the hands only.Methods We analyzed brain gray matter voxel of 1 7 patients (younger than 55 years)with ET of the hands only and 1 7 healthy controls matched in age,gender and education by optimized voxel-based morphometry (VBM).Results VBM showed marked expansion of the bilateral cerebella, occipital fusiform cortices,and precentral lobes (P uncorrected < 0.005 )in ET patients compared with the controls. Atrophy was only detected in left parietal lobe.We also found volume enlargement in the thalamus,midbrain,and melluda of the left side by region of interest (ROI )analysis (P uncorrected <0.005).Conclusion Patients with arm tremor show expansion of gray matter,which might represent the adaptive reorganizational compensation through the increased demand on the visuospatial control of skilled movements in ET patients with early-stage arm tremor. These morphological changes may help to assess early stage and distinguish subtype of ET.