Immunological changes in the serum of elderly patients with primary nephrotic syndrome
10.7652/jdyxb201504022
- VernacularTitle:老年原发性肾病综合征患者血清免疫学的变化
- Author:
Yali ZHANG
;
Xiaoyang YU
;
Yan LI
;
Wenjing ZHANG
;
Meiqun YUAN
;
Xueliang FENG
- Publication Type:Journal Article
- Keywords:
elderly patient;
nephrotic syndrome;
immunoglobulin;
serum complement
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(4):533-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate immunological changes in the serum of elderly patients with primary nephrotic syndrome (PNS).Methods We made a retrospective analysis of clinically relevant immunological parameters and pathological data of PNS patients 60 years old and above (elderly group)in our hospital for kidney biopsy between September 2010 and November 2013.The data of similar patients but younger than 60 years old (control group)were collected for comparison.Results ① The average levels of IgG in serum of the two groups were both lower than the normal level.And the patients with a decreased level accounted for 59.3% in the elderly group and 78.2% in the control group.The results exhibited a significant difference (P <0.05).The elderly group had higher proportions of IgA level in the serum and IgA and IgG/IgM ratio than the control group.The level of IgM in the aged patients,however,was significantly lower than that in the control group (P <0.05 ).The mean concentrations of C3 and C4 in the serum were both in the normal range,and no significant difference was observed (P >0.05).③ IgG had a negative correlation with urinary protein and cholesterol in serum (the values of r were-0.107,-0.238,respectively,P <0.05).However,there was a positive correlation between IgG and albumin (r=0.252,P <0.05).The results in both groups were consistent.④ Membranous nephropathy was the most common pathological type in aged patients while in control group IgA nephropathy was the most common.Conclusion ① The level of IgG in the serum decreases in most aged patients with PNC.The serum IgA and IgG/IgM ratio are elevated while concentrations of C3 and C4 change little.②The change of IgG is correlated with urinary protein, serum albumin and cholesterol in aged patients with PNS.
