Preparation of Osthol Loaded Solid Lipid Nanoparticles
10.3870/yydb.2015.07.030
- VernacularTitle:蛇床子素固体脂质纳米粒制剂的制备
- Author:
Jiaoting CHEN
;
Miaofei WANG
;
Hao HUANG
;
Guoan LUO
- Publication Type:Journal Article
- Keywords:
Osthol;
Solid lipid nanoparticles;
Melt-homogenization method;
Preparation technics
- From:
Herald of Medicine
2015;(7):952-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the main factors affecting the preparation of osthol ( Ost ) loaded solid lipid nanoparticies ( SLN ) . Methods The SLN were prepared by melt-homogenization method. The optimum formulation and process were selected by orthogonai design. The shape, particle size, loading capacity were investigated. Results The obtained Ost-loaded SLN were sphere or oval at a range of 100-200 nm, and were well distributed without adhesion, the loading capacity was 59. 78%. Conclusion The melt-homogenization method is available for the preparation of Ost loaded SLN.
