The potential clinic value of the changes of BAEP and S-100 in the serum as early diagnosis of the bilirubin encephalopathy of newborns

VernacularTitle:血清神经元特异性烯醇化酶及 S-100蛋白变化及其在新生儿胆红素脑病早期诊断中的意义
Author: Lei ZHANG ; Haiying FENG ; Xiaoxiao ZHOU
Publication Type:Journal Article
Keywords: Hyperbilirubinemia; Neonatal; Neuron specific enolase; S-100
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(15):2263-2265
CountryChina
Language:Chinese
Abstract: Objective To explore the potential clinic value of NSE and S-100 in the serum as early diagnosis in the Bilirubin Encephalopathy(BE)of newborns.Methods 46 neborns were choosed as group A with TSB≥342μmol/L;48 with TSB(256-342)μmol/L as group B;and 30 full term deliveries newborns as normal control group C.Their TSB,NSE and S-100 in the serum were measured.Meanwhile,the BAEP scores were carried out.Results The concentrations of NSE,S-100 and the BAEP scores in newborns of group A and B had significant differences as compared with group C (P <0.05 ).Correlation analysis showed that there was a significant positive correlation between serum NSE,S-100 protein and TSB(P <0.05),while there was a negative correlation between serum NSE, S-100 protein and BAEP scores(P <0.05).Conclusion Serum NSE and S-100 protein can use as early diagnosis targets for the the Bilirubin Encephalopathy(BE)of newborns clinically.