The potential clinic value of the changes of BAEP and S-100 in the serum as early diagnosis of the bilirubin encephalopathy of newborns
10.3760/cma.j.issn.1008-6706.2015.15.008
- VernacularTitle:血清神经元特异性烯醇化酶及 S-100蛋白变化及其在新生儿胆红素脑病早期诊断中的意义
- Author:
Lei ZHANG
;
Haiying FENG
;
Xiaoxiao ZHOU
- Publication Type:Journal Article
- Keywords:
Hyperbilirubinemia;
Neonatal;
Neuron specific enolase;
S-100
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2263-2265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential clinic value of NSE and S-100 in the serum as early diagnosis in the Bilirubin Encephalopathy(BE)of newborns.Methods 46 neborns were choosed as group A with TSB≥342μmol/L;48 with TSB(256-342)μmol/L as group B;and 30 full term deliveries newborns as normal control group C.Their TSB,NSE and S-100 in the serum were measured.Meanwhile,the BAEP scores were carried out.Results The concentrations of NSE,S-100 and the BAEP scores in newborns of group A and B had significant differences as compared with group C (P <0.05 ).Correlation analysis showed that there was a significant positive correlation between serum NSE,S-100 protein and TSB(P <0.05),while there was a negative correlation between serum NSE, S-100 protein and BAEP scores(P <0.05).Conclusion Serum NSE and S-100 protein can use as early diagnosis targets for the the Bilirubin Encephalopathy(BE)of newborns clinically.