The clinical effect observation of the non invasive positive pressure mechanical ventilation for the treatment of chronic obstructive pulmonary disease with Ⅱrespiratory failure
10.3760/cma.j.issn.1008-6706.2015.15.034
- VernacularTitle:无创正压机械通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床效果观察
- Author:
Lizhen QUAN
- Publication Type:Journal Article
- Keywords:
Positive pressure ventilation;
Pulmonary disease,chronic obstructive;
Respiratory failure,type II
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2347-2349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the noninvasive positive pressure ventilation combined with pulmonary function and blood gas analysis of chronic obstructive pulmonary disease(COPD)with type Ⅱ respiratory failure. Methods 120 COPD patients with type II respiratory failure were selected,they were randomly divided into the con-trol group and observation group by using the random number table method,with 60 cases each group.The control group was given conventional low flow oxygen therapy,the observation group was application of noninvasive positive pressure ventilation treatment.The change of blood gas levels,the forced expiratory volume in one second (FEV1 ), forced expiratory volume in one second to forced vital capacity ratio (FEV1 /FVC)before treatment and after one week treatment,and the intubation rate,the average hospitalization time were observed.Results After treatment,FEV1 , FEV1 /FVC (%),PaO2 ,pH of the two groups were higher than those before treatment,while PaCO2 was lower than that before treatment,the differences were statistically significant (t =8.33,12.56,14.71,10.82,7.88,10.14, 13.20,15.63,11.48,8.37,all P <0.05).FEV1 and FEV1 /FVC (%)of the observation group after treatment were (2.84 ±0.42)L and (69.93 ±0.72),which were higher than those of the control group after the treatment (2.69 ± 0.39)L and (67.11 ±0.78),the difference was statistically significant (t =8.95,10.76,all P <0.05).PaO2 and pH of the observation group after treatment were (77.90 ±1.12)mmHg and (7.41 ±0.10),which were higher than those of the control group after treatment (70.88 ±1.14)mmHg and (7.29 ±0.08),the difference was statistically significant (t =11.58,7.94,all P <0.05).PaCO2 of the observation group was (50.14 ±1.23)mmHg,which was lower than that of before treatment (54.26 ±1.12)mmHg,the difference was statistically significant (t =9.81,P <0.05).The intubation rate of the observation group was 1.67% (1 /60),which was lower than that of the control group 13.33% (8 /60),the difference was statistically significant (χ2 =7.90,P <0.05).The average hospital stay time of the observation group was (11.69 ±1.32)d,which was lower than that of the control group(15.10 ±1.28)d, the difference was statistically significant (t =9.84,P <0.05).Conclusion Noninvasive positive pressure ventila-tion could significantly improve lung function of COPD patients with type II respiratory failure,increase PaO2 ,improve the respiratory status of the patients,reduce intubation rate and shorten the hospitalization time.
