The effect observation of carvedilol and metoprolol on MMP-9 changes and left ventricular remodeling in patients with hypertension heart disease
10.3760/cma.j.issn.1008-6706.2015.15.036
- VernacularTitle:卡维地洛和美托洛尔对高血压心脏病患者左室重塑及血清基质金属蛋白酶-9水平的影响
- Author:
Xianhua ZHOU
;
Hongwen CAI
- Publication Type:Journal Article
- Keywords:
Hypertension;
Heart disease;
Matri metalloproteinass;
Carvedilol;
Metoprolol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2352-2355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative effect of MMP-9 changes on left ventricular hypertrophy patients with hypertension heart disease by carvedilol and metoprolol.Methods 168 cases were divided into two groups.The control group(84 cases)applied metoprolol.The observation group applied carvedilol.The changes of IVST,LVPWT, LVMI and LVGI,expression of MMP-9 were observed in two groups after treatment.Results The values of IVST, LVPWT,LVMI and LVGI,expression of MMP-9 were decreased after treatment.But the decreased values of IVST [(1.72 ±0.35 )mm vs (0.36 ±0.11 )mm,t =5.75,P <0.05 ],LVPWT[(0.66 ±0.25 )mm vs (0.24 ± 0.18)mm,t =4.32,P <0.05],LVMI[(16.23 ±3.35)g/m2 vs (7.44 ±2.24)g/m2 ,t =9.86,P <0.05 ],LVGI [(0.52 ±0.12)g/m2 vs (0.40 ±0.11)g/m2 ,t =4.24,P <0.05],MMP-9[(76.23 ±20.87)vs(42.55 ±10.87),t =6.54,P <0.05]were higher in the observation group than in the control group.Conclusion The treatment of carvedilol is satisfied,can improve ventricular remodeling,decreased the expression of MMP-9,and is worthy of being recommended in left ventricular hypertrophy patients with hypertension heart disease.
