Outlook and advances in research on miRNAs in cancer
10.7652/jdyxb201504001
- VernacularTitle:肿瘤 miRNAs 调控机制的研究进展与展望
- Author:
Chen HUANG
;
Liying LIU
;
Lei NI
;
Tusheng SONG
- Publication Type:Journal Article
- Keywords:
sncRNA;
miRNA;
expression regulation;
tumor
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(4):429-434
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA)is a kind of non-protein-coding small RNA that is different from mRNA. miRNAs interact with the 3’ untranslated region (3’UTR )of the target mRNA,resulting in either complete degradation or translational inhibition of the target mRNA.miRNAs play a vital role in tumorigenesis,growth, migration and invasion.The regulation of miRNA is closely related to its function in cancer.Competing endogenous RNA (ceRNA),circular RNA (circRNA)and RNA binding protein (RBP)as regulatory molecules are involved in the expression regulation of target genes.It may be one reason why the miRNA has complicated and diversified functions in diverse cancer tissues or cancer cells.The future direction of miRNA research is to study the latest technology to find the network control mechanism of miRNA in the specific cells.
