Meta analysis on the diagnostic value of procalcitonin in early ventilator-associated pneumonia
10.3969/j.issn.1006-5725.2015.13.038
- VernacularTitle:降钙素原检测早期诊断呼吸机相关性肺炎临床价值的Meta分析
- Author:
Xiahui YANG
;
Juan YANG
;
Xiajun CHEN
;
Feipeng CHEN
- Publication Type:Journal Article
- Keywords:
Procalcitonin;
Ventilator-associated pneumonia;
Meta-analysis
- From:
The Journal of Practical Medicine
2015;(13):2186-2189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of procalcitonin in early ventilator-associated pneumonia. Methods CNKI database, Wanfang database and PubMed (2000-2014) were applied for document retrieval through keyword searching approach. Meta-analysis was used in all eligible studies. Results Thirteen studies were collected. The sample bank includes 1 137 cases , of which 599 cases were diagnosed as ventilator-associated pneumonia. Heterogeneity test showed that the homogeneity of the studies was good. The value of the weighted sensitivity was 59% (43% ~ 73%), the specificity was 89% (82% ~ 93%), the positive likelihood ratio was 3.69 (3.21 ~ 4.23), the negative likelihood ratio was 0.42 (0.32 ~ 0.55), and the SROC area under the curve (AUC) was 0.86. The value of the weighted sensitivity was 81%(73% ~ 87%), the specificity was 83%(73% ~ 90%). Conclusion Procalcitonin can be regarded as a valuable marker in early ventilator-associated pneumonia diagnosis , when the cut-off point of PCT is 2.0 μg/L.
