Influence of atorvastatin combined with trimetazidine therapy on blood rheology and endothelial function in elderly patients with unstable angina pectoris
10.3760/cma.j.issn.1008-6706.2015.15.013
- VernacularTitle:阿托伐他汀联合曲美他嗪对老年不稳定型心绞痛患者血液流变学及血管内皮功能的影响
- Author:
Yiping WANG
- Publication Type:Journal Article
- Keywords:
Angina,unstable;
Atorvastatin;
Trimetazidine;
Blood rheology;
Endothelial function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2278-2281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of atorvastatin combined with trimetazidine therapy on blood rheology and endothelial function in elderly patients with unstable angina pectoris.Methods 94 elderly patients with unstable angina pectoris were randomly divided into two groups.Group 1 was treated with ordinary thera-pies,while group 2 was treated in addition of atorvastatin in combination with trimetazidine.The Patients'clinical effects,blood rheology,endothelial function before and after treatment was compared between the two groups.Results The effective rate of group 1 was 74.5%,which was significantly higher than that of group 2(93.6%,P =0.011). The improvement of abnormal ECG turned to be the same result (80.9%,93.6%,P =0.008).There was no differ-ence between the two groups in all above indices (t =0.289,P =0.774;t =0.218,P =0.828;t =0.382,P =0.703;t =0.616,P =0.540;t =1.096,P =0.276;t =0.221,P =0.825;t =0.406,P =0.685).After treatment,the levels of blood and plasma specific viscosity and endothelin-1 in both groups all decreased (group 1:t =6.180,P <0.01;t =10.002,P <0.01;t =4.532,P <0.01;t =4.303,P <0.01;t =4.239,P <0.01;VS group 2:t =15.108,P <0.01;t =14.798,P <0.01;t =7.653,P <0.01;t =7.981,P <0.01;t =8.461,P <0.01),the levels of nitric oxide and FMD all significantly increased (group 1:t =3.627,P <0.01;t =4.833,P <0.01;VS group 2:t =9.945,P <0.01;t =9.707,P <0.01 ),and there was a significantly difference between 2 groups(t =8.750,P <0.01;t =4.388,P <0.01;t =3.415,P <0.01;t =5.132,P <0.01;t =3.052,P =0.003;t =5.754,P <0.01;t =4.503,P <0.01).Conclusion Atorvastatin combined with trimetazidine has an excellent effect on elderly unstable angina pec-toris,with significantly improving blood rheology and endothelial function.
