The clinical observation of different sequences of intravenous administration on sufentanyl-induced cough
10.3760/cma.j.issn.1008-6706.2015.15.015
- VernacularTitle:不同给药顺序对苏芬太尼诱发呛咳反应的临床观察
- Author:
Enhui TANG
;
Zhenxing XU
;
Hao WENG
- Publication Type:Journal Article
- Keywords:
Sufentanyl;
Propofol;
Cough
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2286-2288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different sequences of intravenous administration on sufenta-nyl-induced cough during induction of general anesthesia.Methods One hundred patients,aged 20 ~60 years,weig-hing 45 ~82 kg,ASA Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number table:sufentanyl-propofol group(group SP)and propofol-sufentanyl group(group PS).In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection.Results The incidence of cough was 38%(19 /50)in group SP which was significantly higher than the 12%(6 /50)in group PS(χ2 =9.013,P <0.01);The time of cough was (20.6 ±5.8)s in group SP and (18.8 ± 8.4)s in group PS,which had no statistical significance(t =1.247,P >0.05).Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia.
