Compare of Effects of aspirin and clopidogrel on platelet aggregation function in cerebral infarction patients by thrombelastography
10.3760/cma.j.issn.1008-6706.2015.15.020
- VernacularTitle:血栓弹力图评价阿司匹林与氯吡格雷对脑梗死患者血小板聚集功能的影响
- Author:
Jianjun YANG
;
Shuxin FANG
;
Yongtao LYU
;
Lu LU
;
Yaoyao XING
- Publication Type:Journal Article
- Keywords:
Thrombelastography;
Platelet aggregation;
Aspirin;
Clopidogrel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(15):2301-2303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of aspirin and clopidogrel on platelet aggregation function by TEG,and to study the antiplatelet agents tailored therapy of Thrombelastography(TEG)in treatment of cerebral infarc-tion patients.Methods 100 patients with acute cerebral infarction were included in two groups:aspirin group and clopidogrel group.The inhibitory rates of AA and ADP receptor pathway in platelets were detected by TEG.The effect of inhibitory rates in group aspirin and clopidogrel was compared with nerve function and the recurrence rate of stroke. Results The inhibitory rates of group aspirin (85.23 ±21.98)% was higher than group clopidogrel (47.31 ± 22.37)% (t =7.340,P =0.005).The patients with which the inhibitory rates showed goodby TEG in group aspirin and clopidogrel got better neurological recovery,and the patients showed goodby TEG in group aspirin got lower stroke recurrence rate within 1 year(χ2 =4.460,P =0.035;χ2 =7.232,P =0.007).Conclusion TEG had guided the antiplatelet individual therapy for cerebral infarction patients,and can be used to predict and confirm the efficacy of antiplatelet drug.
