Alteration and clinical significance of cfDNA and CRP in children patients with hand -foot -and -muoth disease
10.3760/cma.j.issn.1008-6706.2015.13.041
- VernacularTitle:手足口病患儿血清循环脱氧核糖核酸和 C 反应蛋白水平的变化及意义
- Author:
Kaiyun HU
;
Hualiang LAI
- Publication Type:Journal Article
- Keywords:
Hand foot and muoth disease;
Deoxyribonucleic acid;
C reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(13):2040-2042
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of changes of serum cfDNA and CRP in patients with hand -foot -and -muoth disease.Methods Serum levels of cfDNA,CPP were measured with fluorescent quan-titation PCR and immunoturbidime,respectively in 108 cases of children patients with hand -foot -and -muoth and 108 healthy subjects children as control group.Results Serum cfDNA and CPP levels with hand -foot -and -muoth group(523.45 ±42.31)mg/L,(22.57 ±5.52)mg/L were significantly higher than those of control group detection results(260.18 ±20.56)mg/L,(2.88 ±0.82)mg/L(t =58.16,36.85,all P <0.05).And we observed the serum cfDNA and CPP levels in different severity extent of pneumonia,the results show that the serum increased gradually with the increase of the severity(t =29.80,13.68,all P <0.05).and the serum level of cfDNA was positive correla-tion with CRP(r =0.730,P <0.01 ).Conclusion The serum.cfDNA and CRP reflect situation of patients and extent of hand -foot -and -muoth disease,which have a close relationship between the clinical process of hand -foot-and -muoth disease and have significance value to evaluate the pathogenetic condition and prognosis.
