The roles of CD4+CD25+ FOXP3+ regulatory T cells and PD-1+CD4+T cells on prognosis of cervical intraepithelial lesion
10.3969/j.issn.1671-8348.2015.18.010
- VernacularTitle:CD4＋CD25＋FOXP3＋调节性T细胞和PD-1＋CD4＋T细胞对宫颈内皮细胞瘤预后的作用
- Author:
Xiuyu LI
;
Bo HU
;
Zhongxin LI
- Publication Type:Journal Article
- Keywords:
human papillomavirus;
cervical intraepithelial lesion;
T-lymphocytes,regulatory;
apoptosis
- From:
Chongqing Medicine
2015;(18):2477-2479
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to investigate the correlation of CD4+ CD25+ FOXP3+ Tregs and PD‐1+ CD4+ T cells located at cervical lesions and the prognosis of CIN .PD‐1 expression on T cells induces Tregs .Methods Cervical lymphocytes were collected from CIN patients and analyzed by FACS .Comparisons were made between populations of cervical Tregs and PD‐1+CD4+T cells in CIN regressors and non‐regressors .Results A median of 11 .8% of cervical CD4+ T cells were CD4+ CD25+ FOXP3+Tregs ,while a median of 30 .3% were PD‐1+ CD4+ T cells .The proportions of CD4+ CD25+ FOXP3+ Tregs and PD‐1+ cells were significantly lower in CIN regressors when compared with non‐regressors .Conclusion The prevalence of CD4+ CD25+ FOXP3+Tregs negative correlates with spontaneous regression of CIN ,suggesting that cervical Tregs may play an important role in HPV‐related neoplastic immunoevasion .
