The expression and role of BAMBI in pancreatic cancer

VernacularTitle:骨形成蛋白和激活素的跨膜抑制剂在胰腺癌中的表达及其意义
Author: Ping WANG ; Haibo LANG ; Xinjuan LIU ; Xue LI ; Hua FAN ; Qiang HE ; Jie ZHANG
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; BMP and activin membrane-bound inhibitor; Immunohistochemistry
From: Chinese Journal of Pancreatology 2015;15(2):78-80
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of BAMBI in pancreatic carcinoma tissue and its clinical value.Methods Expression of BAMBI was detected by immunohistochemistry in 69 cases of pancreatic cancer and 15 normal pancreatic samples.The survival and its association with clinicopathologic parameters were analyzed.Results The expression of BAMBI in the cancer tissue was much higher than that in the normal tissues (56.5％ vs 16.7％,P ＜0.01).The expression of BAMBI was not associated with age,sex and tumor size,differentiation,but expression of BAMBI in patient with lymph node metastasis was higher than that in patient without lymph node metastasis (67.4％ vs 38.5％,P =0.019),the expression of BAMBI in TNM stage Ⅲ was higher than that in stage Ⅰ + Ⅱ (75.0％ vs 31.0％,P =0.001).The median survival of BAMBI-positive group (6 months) was lower than that of BAMBI-negative group (10 months).Conclusions BAMBI is over-expressed in pancreatic carcinoma,and its expression is associated with lymph node metastasis,TNM staging,differentiation and prognosis.