Tumor microevolution and its clinical significance
10.3760/cma.j.issn.1009-9921.2014.10.001
- VernacularTitle:肿瘤的微进化及其临床意义
- Author:
Kefu WU
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
- Publication Type:Journal Article
- Keywords:
Tumor;
Leukemia;
Microevolution;
Branching evolution
- From:
Journal of Leukemia & Lymphoma
2014;23(10):577-580
- CountryChina
- Language:Chinese
-
Abstract:
As novel organisms,tumors undergo microevolution in limited time and space in vivo.Due to genetic mutations and epigenetic mechanisms,tumor cell clones undergo linear or branching evolution.In most clinic patients,tumors develop through branching evolution pathways,causing tumor heterogeneity and affecting tumor progression.Microevolution is the biological basis for the refractoriness and recurrence of tumors and has been paid attention in research and clinic recently.In this paper,acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are used as examples to demonstrate tumor microevolution and the concept of linear and branching evolution.Questions and perspective in the field of tumor microevolution research are also discussed.
