Current pathologic diagnosis and management of Helicobacter pylori-associated gastritis and gastric marginal zone lymphoma with a case report

VernacularTitle:幽门螺杆菌感染性胃炎和胃边缘区淋巴瘤病理诊断及临床治疗进展:附病例报告
Author: Qinglong HU ; Kai FU
Publication Type:Journal Article
Keywords: Mucosa associated lymphoid tissue lymphoma; Helicobacter pylori; Diagnosis; Therapy
From: Journal of Leukemia & Lymphoma 2014;23(11):646-653
CountryChina
Language:Chinese
Abstract: Helicobacter pylori (H.pylori) associated gastritis is one of the most common infectious diseases in China and worldwide.Gastric marginal zone lymphoma,or mucosa associated lymphoid tissue (MALT) lymphoma is a rare neoplasm associated with H.pylori infection and the first neoplastic disease curable by antibiotics therapy alone.The pathologic diagnosis of gastric MALT lymphoma can be reached by histologic examination,immunohistochemical staining,and B-cell clonality studies.Eradication against H.pylori is the choice of therapy for early stage gastric MALT lymphoma.Refractory,localized disease may be treated with low-dose irradiation therapy with high rates of responding and long-term survival.Systemic chemotherapy is recommended for advanced stage gastric MALT lymphoma or high-grade transformed large B-cell lymphoma.A recent case with recurrent chronic active gastritis and gastric MALT lymphoma after H.pylori eradication therapy was reported.Recent advances in the studies of pathologic diagnosis and therapy of the disease were reviewed.