The value of forced expiratory volume in 1 second/forced expiratory volume in 6 second and forced expiratory volume in 6 second in diagnosis of obstructive and restrictive lung ventilation dysfunction
10.3760/cma.j.issn.1673-4904.2014.34.015
- VernacularTitle:第一秒用力呼气容积与第六秒用力呼气容积比值及第六秒用力呼气容积在阻塞及限制性肺通气功能障碍中诊断价值的研究
- Author:
Zhaoshuang ZHONG
;
Ran WANG
;
Shuyue XIA
- Publication Type:Journal Article
- Keywords:
Respiratory function tests;
Pulmonary ventilation disorder;
Forced expiratory volume in 6 second;
Vital capacity
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(34):45-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the value of forced expiratory volume in 6 second (FEV6) and forced expiratory volume in 1 second (FEV1)/FEV6 in diagnosis of obstructive and restrictive lung ventilation dysfunction.Methods A total of 470 cases receiving spirometric examinations were analyzed retrospectively.A subject was considered to have obstruction if FEV1/forced vital capacity (FVC) was ＜ 70％.The restriction was defined as FVC ＜ 80％ in the absence of obstruction.The best cut-off of FEV1/FEV6 and FEV6 were determined through receiver-operating characteristics curve,and the sensitivity,specificity,accuracy and Kappa of FEV1/FEV6 and FEV6 were calculated.Results It showed that the current cut-off points used to detect obstruction and restriction could be replaced by FEV1/FEV6 was 71％ and FEV6 was 82％,respectively.FEV1/FEV6 had sensitivity of 97.5％ (154/158),specificity of 98.7％ (308/312),accuracy of 98.3％ (462/470) and Kappa of 0.962 (P=0.000).For restrictive pattern,FEV6 had sensitivity of 96.1％(73/76),specificity of 95.7％ (222/232),accuracy of 95.8％ (295/308) and Kappa of 0.890 (P =0.000).Conclusions FEV6 can be a valid alternative for FVC in the diagnosis of obstructive and restrictive lung ventilation dysfunction.
