Synthesis and antifungal - antibacterial properties of some chlothiourea and chlorothiosemicarbazide compounds
- Author:
Phuong Truong
- Publication Type:Journal Article
- Keywords:
chlorothiosemicarbazide
- MeSH:
Drug Compounding;
Antifungal Agents;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
2000;295(11):9-11
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
5 thiourea derivatives were synthesized by condensation of 4- chlorophenylisothiocyanat with p-aminobenzoic acide and its derivatives. Condensation of 4-chlorophenylisothiocyanat with phenylhydrazine derivatives to give 2 thiosemicarbazid derivatives. The structure of the obtained products was determined by elementary analysis and IR spectroscopy. The study indicated that all of them have effect on bacteria Gram (+) but this effect on Gram (-) bacteria was weaker. All most of them have effect on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effect on candida albicans.
