Expression of MTSS1 and E-cadherin in upper urinary tract transitional epithelial carcinoma
10.3760/cma.j.issn.1673-4904.2014.32.008
- VernacularTitle:肿瘤转移抑制蛋白及上皮型钙黏蛋白在上尿路移行上皮癌中的表达
- Author:
Huaian CHEN
;
Xueqin BAI
;
Zhe WANG
;
Wenlong MIAO
;
Xiaoyun ZHANG
;
Hongwei SU
;
Shuo LIU
- Publication Type:Journal Article
- Keywords:
MTSS1;
E-cadherin;
Upper tract transitional epithelial carcinoma;
Expression
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(32):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of MTSS1 and E-cadherin expression in upper urinary tract transitional epithelial carcinoma.Methods Paraffin specimens of 60 patients with upper urinary tract transitional epithelial carcinoma between January 2005 and January 2014 were analyzed.At the same time,5 cm normal tissue adjacent to the cancerous tissue specimens in 30 patients were taken for comparison.Immunohistochemical method was used to detect the tissue MTSS1 and E-cadherin expression,and the relationships between their expression with different pathological stage,differentiated degree and lymph node metastasis were analyzed.Results MTSS1 expression rate in normal tissue (100.0％,30/30) was significantly higher than that in cancerous tissue (45.0％,27/60) and there was significant difference (P ＜ 0.05).E-cadherin expression rate in normal tissue (96.7％,29/30) was significantly higher than that in cancerous tissue (41.7％,25/60) and there was significant difference (P ＜ 0.05).The expression of MTSS1 and E-cadherin in different pathological stage,degree and with or without lymph node metastasis had significant difference (P ＜ 0.05).In patients with well differentiated,low TNM stage and no lymph metastasis,MTSS1 and E-cadherin expression rate was higher (P ＜ 0.05).There was no significant correlation between the expression of MTSS 1 and E-cadherin in cancerous tissue (P ＞ 0.05).Conclusion In upper urinary tract transitional cell carcinoma detection of both MTSS1 and E-cadherin has important significance with regards to judging the malignant degree of the tumor,lymph node metastasis and prognosis in patients.
