Human endogenous retroviruses and tumors
10.3760/cma.j.issn.1009-9921.2014.03.003
- VernacularTitle:人类内源性反转录病毒与肿瘤
- Author:
Kefu WU
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
- Publication Type:Journal Article
- Keywords:
Viral etiology;
Human endogenous retroviruses;
Leukemia;
Lymphoma
- From:
Journal of Leukemia & Lymphoma
2014;23(3):137-140
- CountryChina
- Language:Chinese
-
Abstract:
Viral etiology of tumor has been studied for a century.Seven human tumor viruses were identified over the past half century.The complexity and regularity of the pathogenic mechanisms of human tumor viruses have been elucidated preliminarily.Human genome sequencing indicated that 8 ％ of human genes were composed of human endogenous retroviruses (HERVs).Owing to the findings that adult T-cell leukemia virus (HTLV) can cause human adult T-cell leukemia and animal exogenous and HERVs can induce tumors and malignant diseases,the relationship between HERVs and human tumors has attracted much attention receutly.Here this article discusses the association of the expression of HERVs with leukemia and solid tumors progression,which may be an important aspect of tumor virology.
