Diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms
10.3760/cma.j.issn.1673-9752.2014.10.002
- VernacularTitle:胃肠胰神经内分泌肿瘤的诊断与治疗
- Author:
Houjie LIANG
- Publication Type:Journal Article
- Keywords:
Neuroendocrine neoplasms;
Stomach;
Intestine;
Pancreas
- From:
Chinese Journal of Digestive Surgery
2014;13(10):756-759
- CountryChina
- Language:Chinese
-
Abstract:
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are exceedingly rare tumor,with an increasing incidence in recent years.According to the NANETS consensus guidelines for the diagnosis of neuroendocrine tumor,the algorithm for diagnosis of GEP-NENs includes clinical syndrome suggestive of NENs,biochemical testing,genetic testing,tumor localization by imaging and tissue diagnosis.GEP-NENs could be divided into functional versus non-functional based on the clinical manifestations.Radical surgery is the standard firstline therapy for limited-stage tumors.However,two-thirds of GEP-NENs patients are inoperable for tumor metastasis at initial diagnosis.For these advance staged patients,multidisciplinary treatment is the best choice,which includes surgery,chemotherapy,biotherapy,molecular targeted therapy,somatostatin receptor-targeted radionuclide therapy.Molecular targeted therapy may turn into a standard first-line therapy for its good curative effect in recent studies.
