Retrospective analysis of EB virus infection in patients with angioimmunoblastic T-cell lymphoma and its clinical significance

VernacularTitle:血管免疫母细胞性T细胞淋巴瘤患者EB病毒感染情况及其临床意义
Author: Xuemin XUE ; Zifen GAO ; Xiaoyan WANG ; Congyou GU ; Min LI ; Cuiling LIU ; Xin HUANG
Publication Type:Journal Article
Keywords: Lymphoma,T-cell,angioimmunoblastic; EB virus; EBER; Prognosis
From: Journal of Leukemia & Lymphoma 2014;23(2):96-99
CountryChina
Language:Chinese
Abstract: Objective To investigate the EB virus (EBV) infection and its clinical significance in angioimmunoblastic T-cell lymphoma(AITCL).Methods 62 patients diagnosed as AITCL between 2008 Jan and 2011 Dec were retrospective analyzed.All cases were re-confirmed and classified with the histology and immunology according to 2008 WHO Classification.In situ hybridization of EBV encoded RNA (EBV-EBER) was performed.Clinical characteristics and follow-up data of patients were collected.Results 42 ％ (26/62) AITCL cases were EBER-positive.EBV infection was found to be significant correlation with age over 60 years and poor response to therapy (P =0.025,P =0.049,respectively).However,EBV infection had no relationship with the overall survival,the presence of B symptom and the Ann Arbor stage.Conclusion In AITCL,EBV infection seems not to be associated with the overall survival,B symptom and Ann Arbor stage,but it may have impacts on theraputic response.