Curative effect of inhalation of hypertonic saline combined with epinephrine in the treatment of acute moderate and severe bronchiolitis
10.3760/cma.j.issn.1673-4912.2015.01.006
- VernacularTitle:吸入高渗盐水及肾上腺素对治疗急性中重度毛细支气管炎患儿疗效的研究
- Author:
Hao WANG
;
Yunxiao SHANG
- Publication Type:Journal Article
- Keywords:
Bronchiolitis;
Inhalation;
Hypertonic saline;
Epinephrine
- From:
Chinese Pediatric Emergency Medicine
2015;22(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe clinical symptoms and the length of hospital stay of patients with bronchiolitis under different treatment,and the curative effect of inhalation of hypertonic saline combined with epinephrine in the treatment of bronchiolitis.Methods A total of 158 patients with bronchiolitis under 2 years old between August 2012 and May 2013 in Shengjing Hospital of China Medical University were enrolled.According to the admission dyspnea score (respiratory distress assessment instrument,RDAI),all cases were divided into two major groups,moderate group and severe group.Two major groups were randomly divided into three groups (treatment group 1,2,3)according to the different treatments respectively.Patients in the treatment group 1 were inhaled pulmicort combined with combivent,treatment group 2 were inhaled hypertonic saline,and treatment group 3 were inhaled hypertonic saline combined with epinephrine.The symptoms and signs disappeared days,respiratory assessment change score,length of hospital stay and the curative effect in every group were observed before and after the treatment.Results In the moderate group,there were no significant differences in the length of time of cough,wheeze,lung rales disappears as well as the average length of hospital stay between before and after treatment in three treatment groups respectively (P ＞0.05,respectively).In the severe group,there were significant differences in the respiratory assessment change score and length of hospital stay of treatment group 2 and treatment group 3 than that of treatment group 1 respectively(P ＜ 0.05,respectively).There were no significant differences in the length of hospital stay and length of time of cough,wheeze,lung rales disappears between treatment group 2 and treatment group 3 respectively(P ＞ 0.05,respectively).Conclusion There were no significant differences in the curative effect between each treatment group for the moderate bronchiolitis patients.For the severe bronchiolitis patients,hypertonic saline combined with epinephrine inhalation had better curative effect,less adverse reactions.
