The clinical value of N-terminal pro brain natriuretic peptide in septic children with myocardial damage
10.3760/cma.j.issn.1673-4912.2014.12.010
- VernacularTitle:血浆N端B型脑钠肽水平在脓毒症合并心肌损伤患儿中的临床诊断价值
- Author:
Zhenghui XIAO
;
Juan LIU
;
Xiulan LU
;
Zhiyue XU
;
Haiyan LUO
;
Yimin ZHU
- Publication Type:Journal Article
- Keywords:
N-terminal pro brain natriuretic peptide;
Sepsis;
Myocardial damage
- From:
Chinese Pediatric Emergency Medicine
2014;21(12):782-785
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of N-terminal pro brain natriuretic peptide (NT-proBNP) in septic children with myocardial damage.Methods From Jan 1 to Jun 30,2013,162 children confirmed with sepsis in PICU of Hu'nan Children's Hospital were enrolled in the study.Patients were divided into myocardical injury and non-myocardical injury group according to whether accompanied with myocardial injury.NT-proBNP,lactate dehydrogenase,creatine kinase isoenzyme (CK-MB),troponin Ⅰ (cTnⅠ),myoglobin(MB) of patients were measured within 24 h after admission.The NT-proBNP level between two groups was compared.The correlations between NT-proBNP and cTnⅠ,CK-MB were studied respectively.Results The NT-proBNP level[M(Q)] in myocardial injury group[3 632 (668.5,15 453.5) pg/ml] was higher than that in non-myocardial injury group[349 (169,1 500) pg/ml],which was significantly different(Z =91.881,P =0.000).The levels of NT-proBNP,CK-MB,cTnⅠ,MB were abnormal distributions.There were positive correlations between logNT-proBNP and logCK-MB (r =0.367,P =0.000),logcTnⅠ(r =0.304,P =0.001) and logMB (r=0.302,P =0.000).NT-proBNP value of 1 163 ng/ml had a sensitivity of 76％ and a specificity of 74％ to diagnose myocardial injury.Conclusion NT-proBNP could help to diagnose sepsis with myocardial damage.
