Report on the research progress of Hodgkin lymphoma in the 55th ASH annual meeting
10.3760/cma.j.issn.1009-9921.2014.01.007
- VernacularTitle:霍奇金淋巴瘤研究进展与热点:第55届美国血液学会年会报道
- Author:
Zhijian ZOU
;
Wei XU
;
Jianyong LI
- Publication Type:Journal Article
- Keywords:
Hodgkin lymphoma;
ASH annual meeting
- From:
Journal of Leukemia & Lymphoma
2014;23(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
The role of consolidating radiation therapy (RT) is very controversial in Hodgkin lymphoma (HL),especially in adolescents and young adults (AYA) HL.The key problem is how to achieve better therapeutic effect but bear less toxicities in chemotherapy and radiotherapy,which will be hopefully solved by clinical trials adopting interim positron emission tomography (iPET) scanning to guide therapy for HL.The new technologies including whole genome amplification (WGA),high-throughput gene sequencing (NGS) assay and genome-wide association study (GWAS) further illustrate abnormal signaling pathways in HL,such as NF-κB,JAK/STAT and PI3K pathway,which may provide new therapeutic targets for the disease.
