Research progress of biomarkers in neonates following hypoxic-ischemic brain damage
10.3760/cma.j.issn.2095-428X.2015.02.020
- VernacularTitle:新生儿缺氧缺血性脑损伤生物标志物研究进展
- Author:
Nan CHEN
;
Xiaohong WEN
- Publication Type:Journal Article
- Keywords:
Biomarkers;
Hypoxic-ischemic,brain;
Newborn,infant
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;30(2):156-158
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic brain damage (HIBD) is a complex disease process in which injury severity,duration and timing of the antenatal injury are difficult to discern.HIBD triggers a cascade of pathophysiological events (blood-brain barrier damage,oxidative stress,inflammation,glutamate excitotoxicity,energy depletion and cell death) leading to brain damage and neonatal death.Under this background,the changing of biomarkers in different types of biological fluids able to be detected and prognosed HIBD.
