Clinical application of active B-cell antigen receptor signaling as novel therapeutic target in B-cell non-Hodgkin lymphoma
10.3760/cma.j.issn.1009-9921.2013.11.020
- VernacularTitle:靶向B细胞抗原受体信号转导通路小分子抑制剂在B细胞非霍奇金淋巴瘤中的临床应用
- Author:
Ning DING
- Publication Type:Journal Article
- Keywords:
Lymphoma,non-Hodgkin's;
B-cell antigen receptor signal;
Tyrosine kinase;
Target therapy
- From:
Journal of Leukemia & Lymphoma
2013;22(11):700-702
- CountryChina
- Language:Chinese
-
Abstract:
The chronic B-cell antigen receptor (BCR) pathway plays an important role in malignant proliferation of B-cell lymphoma.Several tyrosine kinase inhibitors have shown impressive anti-tumor activity in relapsed and refractory B-cell non-Hodgkin lymphoma.This review discussed essential tyrosine kinases in BCR signaling pathway and present data from clinical usage of these related novel target agents.
