Prognostic value analysis of detection of endothelial progenitor cell in 30 patients with anaplastic large cell lymphoma
10.3760/cma.j.issn.1009-9921.2013.11.004
- VernacularTitle:间变性大细胞淋巴瘤30例患者外周血内皮祖细胞预后价值分析
- Author:
Zhenglei SHEN
;
Liefen YIN
;
Wenwen MAO
;
Jin LIANG
;
Lida SHEN
;
Cunde WANG
;
Ling YANG
- Publication Type:Journal Article
- Keywords:
Endothelial progenitor cell;
Lymphoma,large cell,anaplastic;
Flow cytometry
- From:
Journal of Leukemia & Lymphoma
2013;22(11):655-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To check the changes of endothelial progenitor cell (EPC) number of patients with anaplastic large cell lymphoma (ALCL) in the peripheral blood,investigate their clinical significance.Methods The number of EPC in blood was determined by FCM method in 30 patients with ALCL and 10 healthy cases as the control group.Results The number of EPC in the peripheral blood of patients with ALCL before treatment was significantly higher (15.530±28.659/μl) than that in control group (0.515 ±0.294/μl,P ＜ 0.001).The number of EPC of ALCL patients in the high-risk groups (21.521±36.057/μl) and the middle-risk groups (16.830±24.273/μ1) differently increaasd than that of the low-risk group (6.508±7.356/μl,P ＜ 0.01),but between the high-risk groups and the middle-risk groups there was no significant value (P ＞ 0.05).There were significant difference between the number of EPC of ALK+-ALCL (8.367±9.609/μl) and ALK-ALCL (22.541± 20.845/μl) patients (P ＜ 0.01).The survive curve before 60 weeks had significant difference between groups of ＞20/μl and ＜20/μl of EPC.Conclusion EPC may be correlated with progression of the disease in a certain degree.Dynamic observation with the level of EPC may be used to evaluate the treatment outcomes and act as a prognostic marker for ALCL.
