Recent developments in pathogenesis of Hirschsprung's disease
10.3760/cma.j.issn.2095-428X.2014.23.001
- VernacularTitle:先天性巨结肠发病机制的研究进展
- Author:
Ya GAO
;
Qiang HUANG
- Publication Type:Journal Article
- Keywords:
Hirschsprung's Disease;
Pathogenesis;
Gene network;
Development
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(23):1761-1763
- CountryChina
- Language:Chinese
-
Abstract:
Hirschsprung's disease (HD) is a conginental disorder of enteric nervous system (ENS) and is associated with the abnormal migration of gut neural cerst cell (GNCC).Recent studies showed that the regulation of this migration is a complex gene network.By the development of epigenetic and stem cells,this network is becoming much more clear.Transplantation of the modified gut neural crest stem cells/gut neural crest precursors(GNCSC/GNCP) acquired from the HD bowl is becoming the potential therapy of HD.This paper summerizes the recent advances and is to promote better understanding the pathogenesis of HD.
