Research progress of post-susceptibility genes with bronchopulmonary dysplasia in premature infants

VernacularTitle:早产儿支气管肺发育不良易感基因研究进展
Author: Kun ZHAO ; Shaohan NONG
Publication Type:Journal Article
Keywords: Bronchopulmonary dysplasia; Susceptibility gene; Infant,premature
From: Chinese Journal of Applied Clinical Pediatrics 2015;30(6):476-478
CountryChina
Language:Chinese
Abstract: Bronchopulmonary dysplasia (BPD) is one of the most common serious chronic respiratory diseases in premature infants.In recent years,BPD has been significantly increasing with the improved survival rate of extremely preterm babies.About 10％ of neonates with mechanical ventilation might suffer from BPD,and this may lead to a great burden and costs to both the family and the society.A variety of risk factors has been proposed to be associated with BPD in preterm infants.However recent abroad researches indicated that genetic factors might predispose to BPD of preterm neonates,and initial results of domestic related researches inferred that several susceptibility genes might contribute to BPD development in Han preterm infants.This review focuses on recent publications related to genetic factors that may potentially contribute to BPD.