Clinical characteristics and correlative factors analysis of ANCA-associated vasculitis with interstitial lung disease
10.3760/cma.j.issn.1007-7480.2014.11.010
- VernacularTitle:抗中性粒细胞胞质抗体相关性血管炎合并肺间质病变的临床特点和相关因素分析
- Author:
Juan ZHANG
;
Dawei HU
;
Liping WANG
;
Chunyan WANG
;
Xiaoyuan WANG
- Publication Type:Journal Article
- Keywords:
Antibodies,antineutrophil cytoplasmic;
Lung disease,interstitial;
Vasculitis;
Respiratory tract infections
- From:
Chinese Journal of Rheumatology
2014;18(11):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the clinical characteristics and correlative factors of ANCA-associated systemic vasculitis with interstitial lung disease.Methods Seventy-five AASV patients in Shanghai Renji Hospital from January 2010 to June 2013 were selected.The clinical data of those cases with interstitial lung disease were analyzed retrospectively and logistic regression model was applied to analyze the correlative factors.Results Of the 75 AASV patients,52％ were male,48％ were female,and the average age was (56±19) years.Forty-four cases were defined as interstitial lung disease.Among patients with interstitial lung dis-ease,31 (70％) cases were chronic onset,32(72％) cases had pulmonary infection and 8 (18％) cases died.The main chnical manifestations were dry cough,shortness of breath after labour and fever,the proportion was 68％,36％ and 50％ respectively.Irregular linear shadow was the main imagine changes,the rate was 55％.Pulmonary function changes varied in degrees with diffusion capacity reduction.Multivariate logistic regres-sion analysis showed that those who were older than 60 years (OR=3.44,95％CI:1.05-11.28),positive for MPO-ANCA (OR=3.7,95％CI:1.10-12.65) and Birmingham vasculitis activitv score higher than15 (OR=3.67,95％CI:1.21-11.15) were more likely to have interstitial lung disease.Conclusion Interstitial lung disease is one of the common pulmonary damages of ANCA-associated systemic vasculitis and it will lead to death because of respiratory failure or secondary pulmonary infection.Those who are elders,with positive MPO-ANCA,and with active disease are at high risk for interstitial lung disease among AASV patients.The results of this study sugest that clinicians should pay more attention to patients with these high risk factors.
