A case of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma and literature review
10.3760/cma.j.issn.1009-9921.2014.06.011
- VernacularTitle:原发性皮肤侵袭性亲表皮性CD8+细胞毒性T细胞淋巴瘤一例并文献复习
- Author:
Juan CHEN
;
Jun QIAN
;
Mingzhi FANG
;
Xinghua YANG
;
Xin HUANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,T-cell,cutaneous;
CD8-positive T-lymphocytes;
Cytotoxicity
- From:
Journal of Leukemia & Lymphoma
2014;23(6):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To further elaborate the clinical characteristics,diagnosis,treatment and prognosis of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma.Methods The clinical characteristics,diagnosis and treatment of a patient with primary cutaneous invasive epidermotropic CD8 positive cytotoxicity T-cell lymphoma were summarized,and diagnosis and treatment of the disease from published literature were reviewed.Results After one year long,recurrence of exudative maculopapule on his body and limbs,a middle-aged male patient visited our hospital.Then,the patient was diagnosed as T2N0M0 Ⅰ phase of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma based on results of skin biopsy,immunohistochemistry,T-cell gene rearrangement and PET-CT.Through integrative medicine treatment (combination of bruceolic oil emulsion and chemotherapy with GDP regimen),the patient achieved complete remission (CR).The treatment and follow-up continues till now and his condition was stable.Conclusions Clinical occurrence of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma is rare and early diagnosis is difficult.It could be diagnosed with histopathology combined with T-cell gene rearrangement.In order to avoid misdiagnosis,great caution should be taken during disease history inquiry and physical examination,should be early lesion for delayed healing of recurrent lesions,biopsy should be conducted as soon as possible and immunohistochemistry should be performed simultaneously,which will provide a good basis for further treatment.
