Comparison of clinical-pathological characteristics and prognosis of diffuse large B-cell lymphoma from different origins
10.3760/cma.j.issn.1009-9921.2014.04.005
- VernacularTitle:不同原发部位弥漫大B细胞淋巴瘤临床病理特点及预后比较
- Author:
Cong WANG
;
Changji YUAN
;
Hua HE
;
Ou BAI
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
Primary site;
Clinical characteristic;
Pathological subtype;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2014;23(4):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the difference between nodal and extra-nodal diffuse large B-cell lymphoma (DLBCL) in clinical-pathological feature and prognosis.Methods The clinical data of 134 cases of DLBCL patients were reviewed and analyzed.Results The DLBCL patients accounted for 52.14 ％ (134/257) of non-Hodgkin lymphoma of the same period and the extra-nodal DLBCL patients accounted for 69.4 ％.The proportion of stage Ⅲ/Ⅳ disease in extra-nodal DLBCL and nodal DLBCL were 55.9 ％ (52/93) and 75.6 ％(31/41),respectively.Elevated LDH was reported in 33.3 ％ (31/93) of extra-nodal DLBCL and 58.5 ％ (24/41)of nodal DLBCL Other clinical characteristics such as B symptoms,bulky disease,elevated ESR,ECOG scores and IPI scores were not significantly different between these two groups (all P ＞ 0.05).No difference in the frequency of GCB and non-GCB subtypes was observed between extra-nodal and nodal DLBCL (P =0.623).The 3-year overall survival rates and 3-year progression free survival rates for extra-nodal and nodal DLBCL were 73.2 ％,55.2 ％ (P =0.065) and 46.3 ％,44.1％ (P =0.748).Conclusions The morbidity of extranodal DLBCL is high.Primary extra-nodal DLBCL patients present early-stage disease and normal LDH more frequently than the nodal DLBCL,while no significant difference in the frequency of pathological subtypes and 3-year OS and PFS is observed between these two groups.
