Clinical value of 18F-FDG PET-CT to patients with follicular lymphoma staging Ⅲ-Ⅳ: monitoring response to therapy
10.3760/cma.j.issn.1009-9921.2013.11.001
- VernacularTitle:18F-FDG PET-CT在Ⅲ～Ⅳ期滤泡性淋巴瘤疗效监测中的临床价值
- Author:
Chongyang DING
;
Tiannü LI
;
Wenping YANG
;
Jin SUN
;
Qingjuan HUANG
;
Qiyong DING
;
Wei YANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,follicular;
Positron emission tomography;
Computed tomography;
Fluorodeoxyglucose F18;
Treatment outcome;
Monitoring
- From:
Journal of Leukemia & Lymphoma
2013;22(11):641-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of 18F-FDG PET-CT in monitoring response to therapy in patients with follicular lymphoma (FL) staging Ⅲ-Ⅳ.Methods The clinical data of 20 patients with FL were analyzed retrospectively.All patients underwent PET-CT at three times:baseline,after 3-4 cycles of chemotherapy,and end of treatment.Kaplan-Meier method was used to analyze the survival of patients.Results 14 patients achieved CR at the interim PET-CT,all patients achieved CR at post therapy PET-CT:all patients were alive with no evidence of disease in the follow-up.2 patiens achieved PR at the interim PET-CT,and 1 patient achieved CR,and 1 patient was PD,at post therapy PET-CT,all patients were relapsed in the follow-up.4 patients achieved PD,and all patients were changed the chemotherapy plan.At post therapy PET-CT,2 patients achieved CR,1 patient achieved PR,and 1 patient was PD,1 patient was no evidence of disease,2 patients were relapsed,and another was died in the follow-up.The negative predictive values (NPV) of the interim and the post therapy PET-CT were 100 ％ (14/14),88.2 ％ (15/17) respectively.The interim PET-CT was no significantly correlated with PFS (P =0.135),while the post therapy PET-CT was significantly correlated with PFS (P =0.0006).Conclusion 18F-FDG PET-CT is useful to monitor response to chemotherapy in patients with FL staging Ⅲ-Ⅳ,and set personalized treatment plan.
